Michailidou, KyriakiBeesley, JonathanLindstrom, SaraCanisius, SanderDennis, JoeLush, MichaelMaranian, Mel JBolla, Manjeet KWang, QinShah, MitulPerkins, Barbara JCzene, KamilaEriksson, MikaelDarabi, HatefBrand, Judith SBojesen, Stig ENordestgaard, Børge GFlyger, HenrikNielsen, Sune FRahman, NazneenTurnbull, ClareFletcher, OliviaPeto, JulianGibson, Lornados-Santos-Silva, IsabelChang-Claude, JennyFlesch-Janys, DieterRudolph, AnjaEilber, UrsulaBehrens, SabineNevanlinna, HeliMuranen, Taru AAittomäki, KristiinaBlomqvist, CarlKhan, SofiaAaltonen, KirsimariAhsan, HabibulKibriya, Muhammad GWhittemore, Alice SJohn, Esther MMalone, Kathleen EGammon, Marilie DSantella, Regina MUrsin, GiskeMakalic, EnesSchmidt, Daniel FCasey, GrahamHunter, DavidGapstur, Susan MGaudet, Mia MDiver, W RyanHaiman, Christopher ASchumacher, FredrickHenderson, Brian ELe Marchand, LoicBerg, Christine DChanock, StephenFigueroa, JonineHoover, Robert NLambrechts, DietherNeven, PatrickWildiers, Hansvan Limbergen, ErikSchmidt, Marjanka KBroeks, AnnegienVerhoef, SennoCornelissen, StenCouch, Fergus JOlson, Janet EHallberg, EmilyVachon, CelineWaisfisz, QuintenMeijers-Heijboer, HanneAdank, Muriel Avan der Luijt, Rob BLi, JingmeiLiu, JianjunHumphreys, KeithKang, DaeheeChoi, Ji-YeobPark, Sue KYoo, Keun-YoungMatsuo, KeitaroIto, HidemiIwata, HirojiTajima, KazuoGuénel, PascalTruong, ThérèseMulot, ClaireSanchez, MarieBurwinkel, BarbaraMarme, FrederikSurowy, HaraldSohn, ChristofWu, Anna HTseng, Chiu-chenVan Den Berg, DavidStram, Daniel OGonzález-Neira, AnnaBenitez, JavierZamora, M PilarPerez, Jose Ignacio AriasShu, Xiao-OuLu, WeiGao, Yu-TangCai, HuiCox, AngelaCross, Simon SReed, Malcolm WRAndrulis, Irene LKnight, Julia AGlendon, GordMulligan, Anna MarieSawyer, Elinor JTomlinson, IanKerin, Michael JMiller, NicolaLindblom, AnnikaMargolin, SaraTeo, Soo HwangYip, Cheng HarTaib, Nur Aishah MohdTAN, Gie-HooiHooning, Maartje JHollestelle, AntoinetteMartens, John WMCollée, J MargrietBlot, WilliamSignorello, Lisa BCai, QiuyinHopper, John LSouthey, Melissa CTsimiklis, HelenApicella, CarmelShen, Chen-YangHsiung, Chia-NiWu, Pei-EiHou, Ming-FengKristensen, Vessela NNord, SiljeAlnaes, Grethe I GrenakerGiles, Graham GMilne, Roger LMcLean, CatrionaCanzian, FedericoTrichopoulos, DmitriosPeeters, PetraLund, EilivSund, MalinKhaw, Kay-TeeGunter, Marc JPalli, DomenicoMortensen, Lotte MaxildDossus, LaureHuerta, Jose-MariaMeindl, AlfonsSchmutzler, Rita KSutter, ChristianYang, RongxiMuir, KennethLophatananon, ArtitayaStewart-Brown, SarahSiriwanarangsan, PornthepHartman, MikaelMiao, HuiChia, Kee SengChan, Ching WanFasching, Peter AHein, AlexanderBeckmann, Matthias WHaeberle, LotharBrenner, HermannDieffenbach, Aida KarinaArndt, VolkerStegmaier, ChristaAshworth, AlanOrr, NickSchoemaker, Minouk JSwerdlow, Anthony JBrinton, LouiseGarcia-Closas, MontserratZheng, WeiHalverson, Sandra LShrubsole, MarthaLong, JirongGoldberg, Mark SLabrèche, FranceDumont, MartineWinqvist, RobertPylkäs, KatriJukkola-Vuorinen, ArjaGrip, MerviBrauch, HiltrudHamann, UteBrüning, ThomasRadice, PaoloPeterlongo, PaoloManoukian, SiranoushBernard, LorisBogdanova, Natalia VDörk, ThiloMannermaa, ArtoKataja, VesaKosma, Veli-MattiHartikainen, Jaana MDevilee, PeterTollenaar, Robert AEMSeynaeve, CarolineVan Asperen, Christi JJakubowska, AnnaLubinski, JanJaworska, KatarzynaHuzarski, TomaszSangrajrang, SuleepornGaborieau, ValerieBrennan, PaulMcKay, JamesSlager, SusanToland, Amanda EAmbrosone, Christine BYannoukakos, DrakoulisKabisch, MariaTorres, DianaNeuhausen, Susan LAnton-Culver, HodaLuccarini, CraigBaynes, CarolineAhmed, ShahanaHealey, Catherine STessier, Daniel CVincent, DanielBacot, FrancoisPita, GuillermoAlonso, M RosarioÁlvarez, NuriaHerrero, DanielSimard, JacquesPharoah, Paul PDPKraft, PhillipDunning, Alison MChenevix-Trench, GeorgiaHall, PerEaston, Douglas F2015-11-032015Michailidou, K., J. Beesley, S. Lindstrom, S. Canisius, J. Dennis, M. Lush, M. J. Maranian, et al. 2015. “Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer.” Nature genetics 47 (4): 373-380. doi:10.1038/ng.3242. http://dx.doi.org/10.1038/ng.3242.1061-4036http://nrs.harvard.edu/urn-3:HUL.InstRepos:23474131Genome wide association studies (GWAS) and large scale replication studies have identified common variants in 79 loci associated with breast cancer, explaining ~14% of the familial risk of the disease. To identify new susceptibility loci, we performed a meta-analysis of 11 GWAS comprising of 15,748 breast cancer cases and 18,084 controls, and 46,785 cases and 42,892 controls from 41 studies genotyped on a 200K custom array (iCOGS). Analyses were restricted to women of European ancestry. Genotypes for more than 11M SNPs were generated by imputation using the 1000 Genomes Project reference panel. We identified 15 novel loci associated with breast cancer at P<5×10−8. Combining association analysis with ChIP-Seq data in mammary cell lines and ChIA-PET chromatin interaction data in ENCODE, we identified likely target genes in two regions: SETBP1 on 18q12.3 and RNF115 and PDZK1 on 1q21.1. One association appears to be driven by an amino-acid substitution in EXO1.en-USJournal Article2015-11-0310.1038/ng.3242