Ripke, StephanNeale, BenjaminCorvin, AidenWalters, James TRFarh, Kai-HowHolmans, Peter ALee, PhilBulik-Sullivan, BrendanCollier, David AHuang, HailiangPers, Tune HAgartz, IngridAgerbo, EsbenAlbus, MargotAlexander, MadelineAmin, FarooqBacanu, Silviu ABegemann, MartinBelliveau, Richard ABene, JuditBergen, Sarah EBevilacqua, ElizabethBigdeli, Tim BBlack, Donald WBruggeman, RichardBuccola, Nancy GBuckner, RandyByerley, WilliamCahn, WiepkeCai, GuiqingCampion, DominiqueCantor, Rita MCarr, Vaughan JCarrera, NoaCatts, Stanley VChambert, Kimberley DChan, Raymond CKChan, Ronald YLChen, Eric YHCheng, WeiCheung, Eric FCChong, Siow AnnCloninger, C RobertCohen, DavidCohen, NadineCormican, PaulCraddock, NickCrowley, James JCurtis, DavidDavidson, MichaelDavis, Kenneth LDegenhardt, FranziskaDel Favero, JurgenDemontis, DitteDikeos, DimitrisDinan, TimothyDjurovic, SrdjanDonohoe, GaryDrapeau, ElodieDuan, JubaoDudbridge, FrankDurmishi, NaserEichhammer, PeterEriksson, JohanEscott-Price, ValentinaEssioux, LaurentFanous, Ayman HFarrell, Martilias SFrank, JosefFranke, LudeFreedman, RobertFreimer, Nelson BFriedl, MarionFriedman, Joseph IFromer, MenachemGenovese, GiulioGeorgieva, LyudmilaGiegling, InaGiusti-Rodríguez, PaolaGodard, StephanieGoldstein, Jacqueline IGolimbet, VeraGopal, SrihariGratten, Jacobde Haan, LieuweHammer, ChristianHamshere, Marian LHansen, MarkHansen, ThomasHaroutunian, VahramHartmann, Annette MHenskens, Frans AHerms, StefanHirschhorn, JoelHoffmann, PerHofman, AndreaHollegaard, Mads VHougaard, David MIkeda, MasashiJoa, IngeJulià, AntonioKahn, René SKalaydjieva, LubaKarachanak-Yankova, SenaKarjalainen, JuhaKavanagh, DavidKeller, Matthew CKennedy, James LKhrunin, AndreyKim, YunjungKlovins, JanisKnowles, James AKonte, BettinaKucinskas, VaidutisKucinskiene, Zita AusreleKuzelova-Ptackova, HanaKähler, Anna KLaurent, ClaudineLee, JimmyLee, S HongLegge, Sophie ELerer, BernardLi, MiaoxinLi, TaoLiang, Kung-YeeLieberman, JeffreyLimborska, SvetlanaLoughland, Carmel MLubinski, JanLönnqvist, JoukoMacek, MilanMagnusson, Patrik KEMaher, Brion SMaier, WolfgangMallet, JacquesMarsal, SaraMattheisen, ManuelMattingsdal, MortenMcCarley, Robert WilliamMcDonald, ColmMcIntosh, Andrew MMeier, SandraMeijer, Carin JMelegh, BelaMelle, IngridMesholam-Gately, RaquelleMetspalu, AndresMichie, Patricia TMilani, LiliMilanova, VihraMokrab, YounesMorris, Derek WMors, OleMurphy, Kieran CMurray, Robin MMyin-Germeys, InezMüller-Myhsok, BertramNelis, MariNenadic, IgorNertney, Deborah ANestadt, GeraldNicodemus, Kristin KNikitina-Zake, LieneNisenbaum, LauraNordin, AnnelieO’Callaghan, EadbhardO’Dushlaine, ColmO’Neill, F AnthonyOh, Sang-YunOlincy, AnnOlsen, LineVan Os, JimPantelis, ChristosPapadimitriou, George NPapiol, SergiParkhomenko, ElenaPato, Michele TPaunio, TiinaPejovic-Milovancevic, MilicaPerkins, Diana OPietiläinen, OlliPimm, JonathanPocklington, Andrew JPowell, JohnPrice, AlkesPulver, Ann EPurcell, Shaun MQuested, DigbyRasmussen, Henrik BReichenberg, AbrahamReimers, Mark ARichards, Alexander LRoffman, JoshuaRoussos, PanosRuderfer, Douglas MSalomaa, VeikkoSanders, Alan RSchall, UlrichSchubert, Christian RSchulze, Thomas GSchwab, Sibylle GScolnick, EdwardScott, Rodney JSeidman, Larry JoelShi, JianxinSigurdsson, EngilbertSilagadze, TeimurazSilverman, Jeremy MSim, KangSlominsky, PetrSmoller, JordanSo, Hon-CheongSpencer, Chris C AStahl, Eli AStefansson, HreinnSteinberg, StacyStogmann, ElisabethStraub, Richard EStrengman, EricStrohmaier, JanaStroup, T ScottSubramaniam, MythilySuvisaari, JaanaSvrakic, Dragan MSzatkiewicz, Jin PSöderman, ErikThirumalai, SrinivasToncheva, DragaTosato, SarahVeijola, JuhaWaddington, JohnWalsh, DermotWang, DaiWang, QiangWebb, Bradley TWeiser, MarkWildenauer, Dieter BWilliams, Nigel MWilliams, StephanieWitt, Stephanie HWolen, Aaron RWong, Emily HMWormley, Brandon KXi, Hualin SimonZai, Clement CZheng, XuebinZimprich, FritzWray, Naomi RStefansson, KariVisscher, Peter MAdolfsson, RolfAndreassen, Ole ABlackwood, Douglas HRBramon, ElviraBuxbaum, Joseph DBørglum, Anders DCichon, SvenDarvasi, ArielDomenici, EnricoEhrenreich, HanneloreEsko, TõnuGejman, Pablo VGill, MichaelGurling, HughHultman, Christina MIwata, NakaoJablensky, Assen VJönsson, Erik GKendler, Kenneth SKirov, GeorgeKnight, JoLencz, ToddLevinson, Douglas FLi, Qingqin SLiu, JianjunMalhotra, Anil KMcCarroll, StevenMcQuillin, AndrewMoran, Jennifer LMortensen, Preben BMowry, Bryan JNöthen, Markus MOphoff, Roel AOwen, Michael JPalotie, AarnoPato, Carlos NPetryshen, Tracey L.Posthuma, DanielleRietschel, MarcellaRiley, Brien PRujescu, DanSham, Pak CSklar, PamelaSt Clair, DavidWeinberger, Daniel RWendland, Jens RWerge, ThomasDaly, MarkSullivan, Patrick FO’Donovan, Michael C2015-02-022014Ripke, S., B. M. Neale, A. Corvin, J. T. Walters, K. Farh, P. A. Holmans, P. Lee, et al. 2014. “Biological Insights From 108 Schizophrenia-Associated Genetic Loci.” Nature 511 (7510): 421-427. doi:10.1038/nature13595. http://dx.doi.org/10.1038/nature13595.0028-0836http://nrs.harvard.edu/urn-3:HUL.InstRepos:13890642Summary Schizophrenia is a highly heritable disorder. Genetic risk is conferred by a large number of alleles, including common alleles of small effect that might be detected by genome-wide association studies. Here, we report a multi-stage schizophrenia genome-wide association study of up to 36,989 cases and 113,075 controls. We identify 128 independent associations spanning 108 conservatively defined loci that meet genome-wide significance, 83 of which have not been previously reported. Associations were enriched among genes expressed in brain providing biological plausibility for the findings. Many findings have the potential to provide entirely novel insights into aetiology, but associations at DRD2 and multiple genes involved in glutamatergic neurotransmission highlight molecules of known and potential therapeutic relevance to schizophrenia, and are consistent with leading pathophysiological hypotheses. Independent of genes expressed in brain, associations were enriched among genes expressed in tissues that play important roles in immunity, providing support for the hypothesized link between the immune system and schizophrenia.en-USJournal Article2015-02-0210.1038/nature13595