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Genome-wide association study of colorectal cancer identifies six new susceptibility loci

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dash.depositing.authorGiovannucci, Edward L.::fd8dcb59a5a5859f2a85fabae12a60cf::600
dash.licenseOAP
dash.source.page7138
dash.source.volume6
dash.workflow.comments1Science Serial ID 73040
dc.contributor.authorSchumacher, Fredrick
dc.contributor.authorSchmit, Stephanie
dc.contributor.authorJiao, Shuo
dc.contributor.authorEdlund, Christopher
dc.contributor.authorWang, Hansong
dc.contributor.authorZhang, Ben
dc.contributor.authorHsu, Li
dc.contributor.authorHuang, Shu-Chen
dc.contributor.authorFischer, Christopher
dc.contributor.authorHarju, John
dc.contributor.authorIdos, Gregory
dc.contributor.authorLejbkowicz, Flavio
dc.contributor.authorManion, Frank
dc.contributor.authorMcDonnell, Kevin
dc.contributor.authorMcNeil, Caroline
dc.contributor.authorMelas, Marilena
dc.contributor.authorRennert, Hedy
dc.contributor.authorShi, Wei
dc.contributor.authorThomas, Duncan
dc.contributor.authorVan Den Berg, David J.
dc.contributor.authorHutter, Carolyn
dc.contributor.authorAragaki, Aaron
dc.contributor.authorButterbach, Katja
dc.contributor.authorCaan, Bette
dc.contributor.authorCarlson, Christopher
dc.contributor.authorChanock, Stephen
dc.contributor.authorCurtis, Keith
dc.contributor.authorFuchs, Charles
dc.contributor.authorGala, Manish
dc.contributor.authorGiovannucci, Edward
dc.contributor.authorGogarten, Stephanie
dc.contributor.authorHayes, Richard
dc.contributor.authorHenderson, Brian
dc.contributor.authorHunter, David
dc.contributor.authorJackson, Rebecca
dc.contributor.authorKolonel, Laurence
dc.contributor.authorKooperberg, Charles
dc.contributor.authorSébastien Küry
dc.contributor.authorLaCroix, Andrea
dc.contributor.authorLaurie, Cathy
dc.contributor.authorLaurie, Cecelia
dc.contributor.authorLemire, Mathieu
dc.contributor.authorLevine, David
dc.contributor.authorMa, Jing
dc.contributor.authorMakar, Karen
dc.contributor.authorQu, Conghui
dc.contributor.authorTaverna, Darin
dc.contributor.authorUlrich, Cornelia
dc.contributor.authorWu, Kana
dc.contributor.authorKono, Suminori
dc.contributor.authorWest, Dee
dc.contributor.authorBerndt, Sonja
dc.contributor.authorStéphane Bezieau
dc.contributor.authorBrenner, Hermann
dc.contributor.authorCampbell, Peter
dc.contributor.authorChan, Andrew
dc.contributor.authorChang-Claude, Jenny
dc.contributor.authorCoetzee, Gerhard
dc.contributor.authorConti, David
dc.contributor.authorDuggan, David
dc.contributor.authorFigueiredo, Jane
dc.contributor.authorFortini, Barbara
dc.contributor.authorGallinger, Steven
dc.contributor.authorGauderman, W. James
dc.contributor.authorGiles, Graham
dc.contributor.authorGreen, Roger
dc.contributor.authorHaile, Robert
dc.contributor.authorHarrison, Tabitha
dc.contributor.authorHoffmeister, Michael
dc.contributor.authorHopper, John
dc.contributor.authorHudson, Thomas
dc.contributor.authorJacobs, Eric
dc.contributor.authorIwasaki, Motoki
dc.contributor.authorJee, Sun Ha
dc.contributor.authorJenkins, Mark
dc.contributor.authorJia, Wei-Hua
dc.contributor.authorJoshi, Amit
dc.contributor.authorLi, Li
dc.contributor.authorLindor, Noralene
dc.contributor.authorMatsuo, Keitaro
dc.contributor.authorMoreno, Victor
dc.contributor.authorMukherjee, Bhramar
dc.contributor.authorNewcomb, Polly
dc.contributor.authorPotter, John
dc.contributor.authorRaskin, Leon
dc.contributor.authorRennert, Gad
dc.contributor.authorRosse, Stephanie
dc.contributor.authorSeveri, Gianluca
dc.contributor.authorSchoen, Robert
dc.contributor.authorSeminara, Daniela
dc.contributor.authorShu, Xiao-Ou
dc.contributor.authorSlattery, Martha
dc.contributor.authorTsugane, Shoichiro
dc.contributor.authorWhite, Emily
dc.contributor.authorXiang, Yong-Bing
dc.contributor.authorZanke, Brent
dc.contributor.authorZheng, Wei
dc.contributor.authorLe Marchand, Loic
dc.contributor.authorCasey, Graham
dc.contributor.authorGruber, Stephen
dc.date.accessioned2019-09-23T15:34:06Z
dc.date.available2019-09-23T15:34:06Z
dc.date.issued2015
dc.description.abstractGenetic susceptibility to colorectal cancer is caused by rare pathogenic mutations and common genetic variants that contribute to familial risk. Here we report the results of a two-stage association study with 18,299 cases of colorectal cancer and 19,656 controls, with follow-up of the most statistically significant genetic loci in 4,725 cases and 9,969 controls from two Asian consortia. We describe six new susceptibility loci reaching a genome-wide threshold of P<5.0E - 08. These findings provide additional insight into the underlying biological mechanisms of colorectal cancer and demonstrate the scientific value of large consortia-based genetic epidemiology studies.
dc.description.versionAccepted Manuscript
dc.identifier.citationSchumacher, Fredrick R., Stephanie L. Schmit, Shuo Jiao, Christopher K. Edlund, Hansong Wang, Ben Zhang, Li Hsu, et al. 2015. “Genome-Wide Association Study of Colorectal Cancer Identifies Six New Susceptibility Loci.” Nature Communications 6 (1). https://doi.org/10.1038/ncomms8138.
dc.identifier.doi10.1038/ncomms8138
dc.identifier.issn2041-1723
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:41392051*
dc.language.isoen_US
dc.publisherNature Research (part of Springer Nature)
dc.relation.journalNature Communications
dc.titleGenome-wide association study of colorectal cancer identifies six new susceptibility loci
dc.typeJournal Article
dspace.entity.typePublication
oaire.licenseConditionOAP

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